HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Genofre, E. H. Articles by Marchi, E. Search for Related Content PubMed Articles by Genofre, E. H. Articles by Marchi, E.

Systemic inflammatory acute response in talc pleurodesis using talc of different size particles

Heart Institute (InCor), University of Sao Paulo, Sao Paulo, Brazil

PURPOSE: The side effects reported in talc-induced pleurodesis may be related to migration of talc particles or reflux of inflammatory mediators to the systemic circulation. We hypothesized that different talc size particles may induce different local and systemic inflammatory response.

METHODS: Sixty rabbits were injected intrapleurally with 400 mg/kg of talc with small (< 10um) or normal (>10um). After 6, 24 or 48 hours the animals were killed and had samples of blood collected and assayed for WBC, percent neutrophil (%N), LDH, IL-8 and VEGF. Statistics: t-test.

CONCLUSION: Intrapleural injection of small talc particles produced a more intense systemic effect, with increase in %N, LDH at 48 hours and IL-8 at 24 and 48 hours, whereas normal talc produced greater VEGF levels at all times.

CLINICAL IMPLICATIONS: Small size talc particles may be responsible for a more intense systemic response in talc pleurodesis.

6 hours 24 hours 48 hours small normal small normal small normal WBC (X103) 9,2±3,2 9,9±3,3 8,1±3,2 7,3±2,8 6,1±2,9 7,8±2 % N 69±15 73±11 49±11 45±11 65±12 30±9 LDH (U/L) 362±122 299±91 230±128 223±77 394±155 223±81 IL-8 (pg/mL) 935±400 573±219 1832±751 954±514 2656±1265 1571±365 VEGF (pg/mL) <15 52±15 <15 55±5 <15 69±21 %N p<0,001 small vs normal at 48 hours LDH p<0,05 small vs normal at 48 hours IL-8 p<0,05 small vs normal at 24 and 48 hours VEGF P<0,05 small vs normal at all times

DISCLOSURE: E.H. Genofre, None.