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Cytokines In Pleural Effusion in First 48 Hours After Coronary Artery Bypass Surgery (CABG)

Pulmonary Division - Heart Institute (InCor) - University of Sao Paulo, Brazil

PURPOSE: To evaluate the participation and behavior of cytokines in pleural fluid after 2, 24 and 48 hours after the CABG.

METHODS: Patients were separated into two groups: Control (16 patients with transudative pleural effusion) and CABG (43 patients submitted to CABG). Pleural samples were collected from CABG patients after 2, 24 and 48 hours of the end of surgery. The cytokines TNF-, IL-1Beta, IL-6, IL-8, VEGF and TGF-beta were measured in pleural fluid samples. Transudates effusions were considered according to Light’s criteria. Statistical analysis were done using SPSS software.

RESULTS: IL-1beta, IL-6, VEGF and TGF-beta were analyzed in logarithmic form (Ln) to obtain normality. Results are presented in graphs, and showed that TNF- is not mobilized in the first 48 hours after surgery. IL-1beta increased between 2 and 24 hours after CABG. IL-6 and IL-8 presented expressive levels during 48 hours as well as VEGF. Nevertheless, the TGF-beta levels increased in the first 2 hours and decreased significantly in subsequent times as the transudates levels after 48 hours.

CONCLUSION: Pleural effusion in CABG is related to inflammatory response mediated by IL-1 beta, IL-6, IL-8, VEGF and TGF-beta.

CLINICAL IMPLICATIONS: This profile may be considered in future studies over persistent pleural effusion after CABG.

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