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Tuberculosis: Diagnostic Evaluation


12:30 PM - 2:00 PM

CITOKYNES IN BRONCHOALVEOLAR LAVAGE FROM PATIENTS WITH PULMONARY TUBERCULOSIS AND NEGATIVE SPUTUM

Leila Antonangelo, MD*, Milena M. Acencio, BS, Francisco S. Vargas, MD, Lisete R. Teixeira, MD, Márcia Seiscento, MD, Wilson L. Pedreira, Junior, MD, Gabriela G. Carnevale, PharmD and Viviane R. Figueiredo, MD

Pulmonary Division-Heart Institute (InCor) and Department of Pathology, Universi, Sao Paulo, Brazil

PURPOSE: To evaluate the IL-1ß, TNF-{alpha} and TGFß1 profile in samples of brochoalveolar lavage obtained from patients with pulmonary tuberculosis and negative smear and culture sputum.

METHODS: Samples of bronchoalveolar lavage obtained from 19 patients with pulmonary tuberculosis, 8 patients with others pulmonary diseases and 4 patients without pulmonary disease (control) were evaluated for IL-1ß, TNF{alpha} and TGFß by an ELISA assay. The Kruskal -Wallis one way analysis of variance was used to compare the data between the groups. Significant statistical differences were considered for p< 0.05.

RESULTS: The results are expressed in median (CI 25-75%) and are demonstrated in the table below.

CONCLUSION: We do not observe significant differences for IL-1ß, TNF{alpha} and TGFß among tuberculosis patients, patients with others pulmonary diseases and control group.

CLINICAL IMPLICATIONS: This profile of cytokines do not contribute to differentiate tuberculosis from others pulmonary diseases and must not be used for diagnosis in patients with clinical or radiological suspicion of tuberculosis and negative smear.
Control Tuberculosis Non-Tuberculosis p
IL-1ß 7.8 (7.8-7.8) 7.8 (7.8-31.8) 7.8 (7.8-140.2) 0.515
TNF-{alpha} 15.6 (15.6-15.6) 24.5 (15.6-41.8) 15.6 (15.6-52.7) 0.213
TGF-ß1 31.2 (31.2-31.2) 31.2 (31.2-31.2) 31.2 (31.2-65.2) 0.503

DISCLOSURE: Leila Antonangelo, None.






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