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New York Medical College, Valhalla, NY
PURPOSE: To investigate the prevalence of left ventricular hypertrophy (LVH) in persons with and without obstructive sleep apnea (OSA).
METHODS: We investigated the prevalence of echocardiographic LVH in 53 persons (27 men and 26 women),mean age 51 ± 8 years, who had nocturnal polysomnography for determination of OSA. LVH was diagnosed if the left ventricular mass index exceeded 134 g/m2 in men and 110 g/m2 in women. OSA was considered mild if the respiratory disturbance index (RDI) was 5 to 15, moderate if the RDI was 15 to 30, and severe if the RDI was >30.
RESULTS: Of the 53 persons, 27 (51%) had moderate or severe OSA, 13 (25%) had mild OSA, and 13 (25%) had no OSA. LVH was present in 21 of 27 persons (78%) with severe OSA, in 6 of 13 persons (46%) with mild OSA, and in 3 of 13 persons (23%) with no OSA (p<0.001 comparing moderate or severe OSA with no OSA and p<0.05 comparing moderate or severe OSA with mild OSA). Multiple logistic regression analysis showed that OSA was a significant independent predictor of LVH after controlling the confounding effects of hypertension with an odds ratio of 3.579 (95% confidence interval, 1.589-8.058).
CONCLUSION: OSA is a significant independent predictor of LVH after controlling the confounding effects of hypertension with an odds ratio of 3.579.
CLINICAL IMPLICATIONS: The increased prevalence of LVH in patients with OSA contributes to the increased prevalence of congerstive heart failure in patients with OSA.
DISCLOSURE: Rishi Sukhija, None.
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